Peer-reviewed veterinary case report
Dog with nonunion bone fracture healed using stem cell treatment
By H.B. Lee et al.·Published in Veterinární Medicína·2009·College of Veterinary Medicine, Chonbuk National University, Jeonju, Republic of Korea, CZ·View original on DOAJ →
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Original publication title: Augmentation of bone healing of nonunion fracture using stem cell based tissue engineering in a dog: a case report
- Species:
- dog
Plain-English summary
A 4-year-old male crossbreed dog was brought in for a nonunion fracture, meaning his broken bone wasn't healing properly. The vet used a special treatment involving stem cells taken from the dog's own fat, which were placed on a scaffold made of materials that support bone growth. After the surgery, the dog's fracture healed successfully within three months, with no complications. This innovative approach shows promise for helping dogs with similar bone healing issues.
People also search for: dog nonunion fracture treatment · stem cell therapy for dogs · dog broken bone healing time
Abstract
A 4-year-old, intact male crossbreed dog, weighing 27 kg, was referred for the treatment of a nonunion fracture. The radiographs revealed displacement of the radius and ulna bone fracture fragment and a sclerotic fracture end of the radius. Autologous adipose derived stem cells (ADSCs) were isolated and expanded ex vivo in a culture. The ADSCs (3.2 × 107 cells) were seeded on a composition scaffold made from hydroxyapatite (HA) and chitosan (CH) fibers. The seeded scaffold with ADSCs was placed on the fracture site and the bone fracture was stabilized. A sample of seeded scaffold with ADSCs was taken to evaluate the extent of cell attachment and morphology on the scaffold using scanning electron microscopy (SEM). SEM showed that ADSCs adhered to the scaffold well and many bone nodules formed from the bone matrix secreted by ADSCs. Three months after surgery, the nonunion had successfully healed with no complications. The application of a composition scaffold of HA and CH containing ADSCs can be used to treat a nonunion fracture by augmenting bone healing and may decrease the risk of surgical failure of nonunion fractures.
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Search related cases →Original publication on DOAJ: https://doi.org/10.17221/3024-VETMED