Peer-reviewed veterinary case report
Dog with autoimmune disease causing low adrenal function and diabetes
By Hwang, Seo-Young et al.·Published in Veterinary medicine and science·2021·Department of Veterinary Clinical Science, South Korea·View original on PubMed →
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Original publication title: Autoimmune polyendocrine syndrome with hypoadrenocorticism and diabetes mellitus in a dog: A rare case.
- Species:
- dog
Plain-English summary
A 9-year-old spayed female miniature poodle was brought to the vet because she was not eating, seemed very depressed, and was vomiting. Tests showed she had low sodium and chloride levels, along with repeated low blood sugar, leading to a diagnosis of hypoadrenocorticism (a condition where the adrenal glands don't produce enough hormones) alongside her existing diabetes. The vet treated her with an injection of deoxycorticosterone pivalate and increased her oral prednisolone dose, which helped improve her overall condition.
People also search for: dog vomiting and not eating · miniature poodle diabetes treatment · hypoadrenocorticism in dogs
Abstract
BACKGROUND: Autoimmune polyendocrine syndrome, also called polyglandular autoimmune syndrome, is a rare immune-mediated disorder that involves various endocrine glands. PURPOSE: To report autoimmune polyendocrine syndrome in a dog. METHODS: A 9-year-old spayed female miniature poodle diagnosed with insulin-dependent diabetes mellitus emergently visited our clinic for anorexia, severe depression, and vomiting. Hyponatremia, hypochloridemia, and recurrent hypoglycaemia were found. Hypoadrenocorticism was diagnosed based on consistent clinical signs and repeated adrenocorticotropic hormone stimulation tests. RESULTS: After injecting deoxycorticosterone pivalate and increasing the oral prednisolone dose, the patient's systemic condition improved. CONCLUSIONS: To the best of our knowledge, this is the first case report of hypoadrenocorticism concurrent with diabetes mellitus in a dog. Furthermore, we would like to present the probability of an immune-mediated disorder with multiple organs involved, like type IV autoimmune polyendocrine syndrome in humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34480407/