Peer-reviewed veterinary case report
Using a dog's own ligament cells to treat gum bone defects in teeth
By Suaid, Fabricia Ferreira et al.·Published in Journal of clinical periodontology·2011·Department of Prosthodontics and Periodontics, Brazil·View original on PubMed →
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Original publication title: Autologous periodontal ligament cells in the treatment of class II furcation defects: a study in dogs.
- Species:
- dog
Plain-English summary
A group of seven dogs with gum disease affecting their teeth underwent a new treatment using their own periodontal ligament cells (PDL cells) to help regenerate damaged tissue. After extracting teeth and culturing the cells, the dogs received either the PDL cells combined with guided tissue regeneration (GTR) or just GTR alone. Three months later, the dogs that received the PDL cells showed significantly better healing, with more new bone and gum tissue formed compared to those that only had GTR. This suggests that using PDL cells can be an effective way to treat certain dental issues in dogs.
People also search for: dog gum disease treatment · periodontal ligament cells for dogs · guided tissue regeneration in dogs
Abstract
AIM: The goal of this study was to histologically investigate the use of periodontal ligament cells (PDL cells) in tissue engineering to regenerate class II furcation defects. MATERIAL AND METHODS: PDL cells were obtained from the mandibular tooth extracted from each dog (seven), cultured in vitro and phenotypically characterized with regard to their biological properties. Following, bilateral class II furcation lesions were created at maxillary 3rd premolars and were randomly assigned to the test group [PDL cells+guided tissue regeneration (GTR)] or the control group (GTR). After 3 months, the animals were euthanized to evaluate the histometric parameters. RESULTS: In vitro, PDL cells were able to promote mineral nodule formation and to express bone sialoprotein, type I collagen and alkaline phosphatase. Histometrically, data analysis demonstrated that the cell-treated group presented a superior length of new cementum (6.00 ± 1.50 and 8.08 ± 1.08 mm), a greater extension of periodontal regeneration (3.94 ± 1.20 and 7.28 ± 1.00 mm), a lower formation of connective tissue/epithelium (2.15 ± 1.92 and 0.60 ± 0.99 mm), a larger area of new bone (7.01 ± 0.61 and 9.02 ± 2.30 mm(2)) and a smaller area of connective tissue/epithelium (5.90 ± 1.67 and 4.22 ± 0.95 mm(2)), when compared with control group. CONCLUSION: PDL cells in association with GTR may significantly promote periodontal regeneration in class II furcation defects in dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21392047/