Peer-reviewed veterinary case report
Platelet-rich fibrin helps skin wounds heal faster in cats
By Zhang, Shuai et al.·Published in BMC veterinary research·2024·College of Veterinary Medicine, China·View original on PubMed →
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Original publication title: Autologous platelet-rich fibrin enhances skin wound healing in a feline trauma model.
- Species:
- cat
Plain-English summary
A group of 18 cats with skin wounds from trauma were treated with either platelet-rich fibrin (PRF) or Manuka honey to see which helped heal their wounds faster. The study found that PRF not only sped up the healing process but also helped reduce inflammation and promote the growth of new tissue. Both treatments showed similar positive results, with PRF being safe and effective without affecting the cats' vital signs. This suggests that PRF could be a beneficial option for treating skin wounds in cats.
People also search for: cat skin wound treatment · platelet-rich fibrin for cat wounds · Manuka honey for cat injuries
Abstract
Trauma is a common cause of cutaneous surgical disease with an increased risk of secondary infection in cat clinics. Platelet-rich fibrin (PRF), a platelet and leukocyte concentrate containing multiple cytokines and growth factors, is known to accelerate the healing of wounds. However, how PRF affects wound healing in the cat trauma model has not been fully investigated. The study aimed to examine the impact of PRF on skin wound healing in the cat trauma model. In this study, PRF from cats was successfully produced for our investigation. The models of feline trauma were effectively established. A total of 18 cats were randomly divided into 3 groups (n = 6): (1) Control group (CON); (2) PRF group; (3) Manuka honey group (MAN, as a positive control). Experiments were performed separately on days 7, 14, 21, and 28. Our results showed that PRF was a safe and efficient method of wound healing that did not influence the cat's body temperature, respiration rate, and heart rate (HR). PRF accelerated skin wound healing in the cat trauma model based on the rate and histological observation of wound healing. In addition, PRF promoted the production of growth factors and suppressed inflammation during wound healing. PRF accelerated wound healing by increasing the formation of collagen fibers, as shown by Masson-trichrome staining. The outcomes of the PRF and MAN groups were comparable. In conclusion, PRF improves the healing of skin wounds in cats by boosting the synthesis of growth factors, reducing inflammation, and enhancing the synthesis of collagen fibers.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39508248/