Peer-reviewed veterinary case report
AVE 0991-angiotensin-(1-7) receptor agonist, inhibits atherogenesis in apoE-knockout mice.
- Journal:
- Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
- Year:
- 2010
- Authors:
- Toton-Zuranska, J et al.
- Affiliation:
- Jagiellonian University Medical College
- Species:
- rodent
Abstract
Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes. It was also proved that Ang II promotes atherogenesis. Angiotensin-(1-7) [Ang-(1-7)] opposites Ang II action. Therefore, we would like to find out whether Ang-(1-7) receptor agonist: AVE 0991, could ameliorate atherosclerosis progression in an experimental model of atherosclerosis: apolipoprotein E (apoE) - knockout mice. AVE 0991 inhibited atherogenesis, measured both by "en face" method (7.63+/-1.6% vs. 14.6+/-2.1%) and "cross-section" method (47 235+/-7 546 microm(2) vs. 91 416+/-8 357 microm(2)). This is the first report showing the effect of AVE 0991 on atherogenesis in gene-targeted mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20436218/