Peer-reviewed veterinary case report
Axonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dynein.
- Journal:
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Year:
- 2017
- Authors:
- Finnie, John W & Manavis, Jim
- Affiliation:
- Hanson Institute Centre for Neurological Diseases and Schools of Medicine and Veterinary Science · Australia
Abstract
Neuroaxonal dystrophy (NAD) is a neurologic disorder of sheep characterized by accumulation of numerous axonal swellings (spheroids) in specific regions of the brainstem and spinal cord. Disruption of axonal transport, which is driven in anterograde and retrograde directions by the molecular motors, kinesin and dynein, respectively, is believed to contribute to spheroid development. Accordingly, we examined spheroids in ovine NAD cases immunohistochemically for kinesin and dynein and found both motor proteins, with dynein more strongly expressed than kinesin. Further investigations of the kinesin and dynein content of axonal spheroids in NAD, and other neurodegenerative disorders of domestic animals, could assist in better understanding the pathogenesis of these diseases.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28754069/