Peer-reviewed veterinary case report
Azithromycin levels in severely inflamed dog ear canals after oral
By Perry, E et al.·Published in The Journal of small animal practice·2020·Veterinary Teaching Hospital·View original on PubMed →
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Original publication title: Azithromycin concentration in severely inflamed canine external ear canals - a case series.
- Species:
- dog
Plain-English summary
Five dogs with severe ear infections underwent surgery to fix their ear canals. Before the surgery, they were given a single dose of azithromycin, an antibiotic, to see how much of it would concentrate in their inflamed ear tissues. The results showed that the antibiotic levels in the ear tissue were significant, suggesting it could be effective in treating chronic ear infections in dogs. This study indicates that azithromycin might be a useful treatment option for dogs suffering from severe ear problems.
People also search for: dog ear infection treatment · azithromycin for dogs · chronic otitis externa in dogs
Abstract
OBJECTIVE: To determine azithromycin concentration in severely inflamed canine external ear canals. MATERIAL AND METHODS: Five dogs of various breeds and ages with severe and chronic otitis externa underwent ear canal reconstruction surgery. A single oral dose of azithromycin at 10 mg/kg was administered 12 to 24 hours prior to surgery. Tissue samples were collected from the excised external ear canals and azithromycin concentration was determined using a liquid chromatography-tandem mass spectrometry method. RESULTS: Azithromycin concentrations ranging from 11.4 to 107.0 μg/g (mean 59.2 ± 44.6 μg/g, median 50.9 μg/g) were detected in the chronically infected external ear canal tissue 12 to 24 hours after administration. CLINICAL SIGNIFICANCE: Little information exists on antibiotic concentrations in pathological tissues of dogs. Macrolides are known to concentrate in skin tissue. In light of the present results, investigation of clinical efficacy of azithromycin in chronic canine otitis externa is warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32715501/