Peer-reviewed veterinary case report
Azithromycin levels in blood and skin of healthy and pyoderma dogs
By Zur, Gila et al.·Published in Veterinary journal (London, England : 1997)·2014·Veterinary Teaching Hospital·View original on PubMed →
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Original publication title: Azithromycin pharmacokinetics in the serum and its distribution to the skin in healthy dogs and dogs with pyoderma.
- Species:
- dog
Plain-English summary
A group of healthy dogs and dogs with skin infections (pyoderma) were given azithromycin, an antibiotic, to see how well it worked in their bodies. The healthy dogs received the medication for three days, while the dogs with pyoderma were treated twice with a week in between. The results showed that azithromycin was quickly absorbed and stayed in the body for a long time. In dogs with skin infections, the concentration of the drug in their skin was much higher than in their blood, which suggests it could be effective for treating skin problems.
People also search for: dog skin infection treatment · azithromycin for dogs · pyoderma in dogs symptoms
Abstract
Serum and skin tissue azithromycin (AZM) concentrations were analysed in healthy and pyoderma affected dogs to determine AZM pharmacokinetics and to establish the effect of disease on AZM skin disposition. AZM was administered orally to two groups of healthy dogs: (1) at 7.02 mg/kg (n=7) and (2) at 11.2mg/kg (n=9). A crossover design was used on five of them. Seven dogs with pyoderma were treated with AZM at 10.7 mg/kg. The two groups of healthy dogs received AZM once daily over three consecutive days and dogs with pyoderma received the same treatment repeated twice with an interval of 1 week. AZM concentrations were determined by liquid chromatography-tandem mass spectrometry. AZM was rapidly absorbed and slowly excreted. In healthy dogs, maximum serum concentrations appeared 2h after administration and were (mean ± standard deviation) 0.60 ± 0.25 μg/mL and 1.03 ± 0.43 μg/mL, and the half-lives were 49.9 ± 5.10 and 51.9 ± 6.69 h for doses of 7.02 and 11.2mg/kg, respectively. Clearance (CL0-24/F) was similar in both dosing groups (1.24 ± 0.24 and 1.29 ± 0.24 L/h/kg) and the respective mean residence time (MRT0-24) was 11.1 ± 0.8 and 8.4 ± 2.2h. The skin concentration in healthy dogs was 3.5-6.5 and 5.0-12.0 times higher than the corresponding serum concentration after the two doses and increased after the cessation of AZM administration. The ratio increased significantly in inflamed tissue (9.5-26.2).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24472431/