Peer-reviewed veterinary case report
Testing antifungal drug effectiveness for Malassezia pachydermatis
By Murayama, Nobuo & Kano, Rui·Published in The Journal of veterinary medical science·2023·Dermatology Services for Dogs and Cats, Japan·View original on PubMed →
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Original publication title: Azole and terbinafine susceptibility testing of Malassezia pachydermatis in Japan.
- Species:
- dog
Plain-English summary
A dog with skin and ear infections caused by a yeast called Malassezia pachydermatis was treated with antifungal medications. Researchers found that some strains of this yeast were resistant to common antifungals like itraconazole and miconazole, but they were more susceptible to terbinafine. This means that terbinafine could be a better option for treating these infections in dogs that don't respond to other antifungals. If your dog has persistent skin or ear issues, terbinafine might be worth discussing with your vet.
People also search for: dog skin infection treatment · Malassezia dermatitis in dogs · terbinafine for dog ear infection
Abstract
Canine Malassezia dermatitis and otitis externa are generally treated by antifungal drugs. However, multi-drug-resistant strains of Malassezia pachydermatis have been reported worldwide. Given the presence of these multi-drug-resistant strains, it is unclear which antifungal agent is the most effective for canine Malassezia dermatitis and canine otitis. In this study, we attempted to determine the most effective drug against azole-resistant M. pachydermatis. Susceptibility to azoles and terbinafine (TBF) was assessed using a modified broth microdilution method. In all tested isolates, the minimum inhibitory concentration at 90% of organisms (MIC) were 16 to >32 μg/mL for the azoles, and 2 μg/mL for TBF. All of the strains that showed low susceptibility to both itraconazole and miconazole were also relatively susceptible to TBF.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36724970/