Peer-reviewed veterinary case report
Azole antifungal resistance in dog and cat Aspergillus fumigatus
By Talbot, Jessica J et al.·Published in Comparative immunology, microbiology and infectious diseases·2015·Faculty of Veterinary Science, Australia·View original on PubMed →
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Original publication title: Azole resistance in canine and feline isolates of Aspergillus fumigatus.
- Species:
- dog
Plain-English summary
A study looked at 46 dogs and 4 cats with a fungal infection called sino-nasal aspergillosis, which can cause symptoms like nasal discharge and sneezing. Researchers tested how well different antifungal medications worked against the fungus Aspergillus fumigatus from these pets. They found that most of the samples were still sensitive to common treatments, meaning that topical antifungal medications should still be effective for most pets with this condition. However, one dog from 1992 showed resistance to multiple antifungal drugs, but this was not seen in more recent cases.
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Abstract
Azole resistance is an emerging cause of treatment failure in humans with aspergillosis. The aim of this study was to determine if azole resistance is emerging in Aspergillus fumigatus isolates from canine and feline sino-nasal aspergillosis cases. Susceptibilities of isolates collected between 1988 and 2014 from 46 dogs and 4 cats to itraconazole, posaconazole, voriconazole, fluconazole and ketoconazole were assessed using Sensititre YeastOne microdilution trays; and to enilconazole and clotrimazole, following the CLSI M38-A2 standard. For the majority of isolates MICs were high for ketoconazole, low for enilconazole and clotrimazole, and less than established epidemiological cut-off values for itraconazole, posaconazole and voriconazole. One canine isolate from 1992 had multiazole resistance and on Cyp51A gene sequencing a mutation associated with azole resistance (F46Y) was detected. There is no evidence of emerging azole resistance among A. fumigatus isolates from dogs and cats and topical azole therapy should be effective against most isolates.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26387063/