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Peer-reviewed veterinary case report

Back-to-BACs in Huntington's disease modeling.

Journal:
Neuron
Year:
2022
Authors:
Lee, Hyeseung & Heiman, Myriam
Affiliation:
Picower Institute for Learning and Memory · United States

Abstract

In this issue of Neuron, Gu et al. (2022) describe a new BAC mouse model that faithfully recapitulates various aspects of Huntington's disease pathobiology and reveals important insights into the relative toxicities of mHTT-derived products.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/35390285/