Peer-reviewed veterinary case report
Bacterium-Expressed dsRNA Downregulates Microsporidia Nosema bombycis Gene Expression.
- Journal:
- The Journal of eukaryotic microbiology
- Year:
- 2017
- Authors:
- Pan, Qiuling et al.
- Affiliation:
- College of Life sciences · China
Abstract
The microsporidia Nosema bombycis is the insect pathogen of pebrine disease severely destructive to sericulture production. Here, we describe the use of Escherichia coli HT115 strain (DE3) to express double-strand RNAs targeting the gene encoding ADP/ATP protein in N. bombycis. The results showed that dsRNAs deferentially suppressed the gene expression during N. bombycis infection in the silkworm, and the effect waned gradually. Our results, for the first time, provide a tool to utilize the dsRNA expressed by recombinant E. coli to control the pebrine disease of the domestic silkworm.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27397809/