Peer-reviewed veterinary case report
Baloxavir improves disease outcomes in mice after intranasal or ocular infection with Influenza A virus H5N1-contaminated cow's milk.
- Journal:
- Nature microbiology
- Year:
- 2025
- Authors:
- Jones, Jeremy C et al.
- Affiliation:
- Department of Host-Microbe Interactions · United States
- Species:
- rodent
Abstract
Testing approved antivirals against A(H5N1) influenza viruses circulating in peridomestic species, including dairy cows, is critical to public health and pre-pandemic planning. It cannot be tested in humans due to A(H5N1) disease severity. Here, in mice, we demonstrate that US FDA-approved baloxavir treatment mediates improved disease outcomes (survival and viral dissemination) over oseltamivir after lethal intranasal and ocular challenge with A(H5N1)-contaminated cow milk.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40097765/