Peer-reviewed veterinary case report
Basal cell count does not predict cancer in dog perianal tumors
By Evans, Samantha J M et al.·Published in Veterinary clinical pathology·2018·College of Veterinary Medicine and Biomedical Science, United States·View original on PubMed →
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Original publication title: Basal cell enumeration does not predict malignancy in canine perianal gland tumor cytology.
- Species:
- dog
Plain-English summary
A group of dogs with perianal gland tumors, which are common in canines, was studied to see if the number of small basal cells in their tumor samples could indicate whether the tumors were benign or malignant. Out of 83 cases, only 6 were found to be malignant, but the researchers discovered that the proportion of basal cells did not help in predicting malignancy. This means that pet owners and veterinarians should not rely on basal cell counts in cytology reports to determine the seriousness of these tumors.
People also search for: dog perianal gland tumor symptoms · how to treat perianal tumors in dogs · are perianal tumors in dogs cancerous
Abstract
BACKGROUND: Perianal (hepatoid) gland tumors are common in dogs, and the distinction between the benign and malignant forms is clinically important. Cytology of these tumors typically contains many large hepatoid cells and fewer small basal cells. OBJECTIVES: The objective of this study was to determine whether the proportion of the smaller basaloid reserve cells in cytologic samples from perianal tumors correlates with malignancy. METHODS: Eighty-three cases of cytologically diagnosed perianal gland tumors with corresponding histopathologic sections were identified from two separate institutions and included six (7.2%) malignant tumors and 77 (92.8%) benign tumors. The proportion of basal cells from each sample was evaluated. RESULTS: No difference between these groups was found, although the study was sufficiently powered to detect an approximately 1.5-fold change in basal cell proportion. CONCLUSIONS: This report found no evidence that the proportion of basal cells in canine perianal tumor cytology is an indication of the potential for malignancy. We, therefore, do not recommend citing this feature in cytologic reports or when communicating with clinicians.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30415503/