Berk Alleviated Atherosclerosis Symptoms via Nuclear Factor-Kappa B-Mediated Inflammatory Response in ApoEMice.

Abstract

BACKGROUND: Atherosclerosis, a persistent inflammatory disease marked by the presence of atherosclerotic plaques or fibrous plaques, is a significant contributor to the onset of the development of cardiovascular disease.Berk contains various active ingredients that have anti-inflammatory, antioxidant, and hypolipidemic properties. Nevertheless, the potential effects ofon atherosclerosis have not been systematically reported. METHOD: In this study, ApoEmice were employed as models of atherosclerosis caused by a high-fat diet (HFD) to investigate the effect of. Gut microbiota and serum metabolism analysis were performed to elucidate the potential mechanism offor its anti-atherosclerosis effects. RESULTS: significantly decreased the aortic root wall thickness and the area of lipid droplets, regulated lipid levels, and inhibited fat accumulation to improve aortic root lesions. Furthermore,significantly altered serum metabolite (including diethyl phthalate and succinate) levels, regulated the abundance of microbiota, such asand, and suppressed the inflammatory response to ameliorate atherosclerosis via the nuclear factor-kappa B (NF-κB)-mediated inflammatory response in HFD-induced ApoEmice. CONCLUSIONS: These results offer a theoretical basis and data to supportas a potential strategy for treating atherosclerosis.