Peer-reviewed veterinary case report
beta-Alkylthio indolyl carbinols: potent nonsteroidal antiandrogens with oral efficacy in a prostate cancer model.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2007
- Authors:
- Lanter, James C et al.
- Affiliation:
- Johnson & Johnson Pharmaceutical Research and Development L.L.C. · United States
- Species:
- rodent
Abstract
Through an in vivo screening model, we developed the in vivo SAR of beta-alkylthio indolyl carbinols. Through these efforts we identified a compound with potent oral in vivo efficacy in both immature and mature rat prostate weight reduction models and in a murine xenograft prostate cancer model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17337185/