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Peer-reviewed veterinary case report

Bidirectional Communication: The Gut-Brain Axis in Companion Animal Health.

Journal:
The Veterinary clinics of North America. Small animal practice
Year:
2026
Authors:
Albright, Julia D & Haug, Lore I
Affiliation:
Department of Small Animal Clinical Sciences · United States

Abstract

The microbiome-gut-brain axis (MGBA) is a complex network of gastrointestinal (GI) microbiota and host enteric, immune, neural, endocrine, and metabolic pathways. Disruptions to homeostasis promote dysbiosis, immune dysregulation, inflammation, and vagal signal disruption. Many disease states and behavioral disorders are associated with a change in GI microbial composition and diversity. Psychoactive treatments may specifically target the MGBA to reduce systemic and neuroinflammation linked to the pathogenesis of many GI and neuropsychiatric conditions.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/41786560/