Peer-reviewed veterinary case report
Bifidobacterium breve B-3 exerts metabolic syndrome-suppressing effects in the liver of diet-induced obese mice: a DNA microarray analysis.
- Journal:
- Beneficial microbes
- Year:
- 2013
- Authors:
- Kondo, S et al.
- Affiliation:
- Food Science and Technology Institute · Japan
- Species:
- rodent
Abstract
We previously reported that supplementation with Bifidobacterium breve B-3 reduced body weight gain and accumulation of visceral fat in a dose-dependent manner, and improved serum levels of total cholesterol, glucose and insulin in a mouse model of diet-induced obesity. In this study, we investigated the expression of genes in the liver using DNA microarray analysis and q-PCR to reveal the mechanism of these anti-obesity effects in this mouse model. Administration of B. breve B-3 led to regulated gene expression of pathways involved in lipid metabolism and response to stress. The results indicate that these regulations in the liver are related to the anti-metabolic syndrome effects of B. breve B-3.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23666099/