Peer-reviewed veterinary case report
Big endothelin-1 blood test detects canine splenic haemangiosarcoma
By Fukumoto, Shinya et al.·Published in Veterinary journal (London, England : 1997)·2015·Department of Small Animal Clinical Sciences, Japan·View original on PubMed →
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Original publication title: Big endothelin-1 as a tumour marker for canine haemangiosarcoma.
- Species:
- dog
Plain-English summary
A study found that dogs with a type of cancer called hemangiosarcoma (HSA) had significantly higher levels of a substance called big endothelin-1 in their blood compared to dogs with other types of tumors or healthy dogs. This means that measuring big endothelin-1 could help veterinarians diagnose HSA more accurately. The test showed a 100% sensitivity and 95% specificity for identifying this cancer, making it a promising tool for early detection. If your dog is showing symptoms like lethargy, weakness, or swelling in the abdomen, it’s important to discuss this potential test with your veterinarian.
People also search for: dog cancer symptoms · hemangiosarcoma diagnosis in dogs · big endothelin-1 test for dogs
Abstract
Haemangiosarcoma (HSA) is an important malignant neoplasm of dogs that originates from vascular endothelial cells. This study explored the suitability of using serum big endothelin-1 (ET-1) as a tumour marker for canine spontaneous HSA. Serum big ET-1 was measured in dogs with splenic HSA (n = 14), splenic malignant tumours other than HSA (n = 10), benign splenic lesions (n = 11) and normal healthy dogs (n = 17) by ELISA. Serum big ET-1 levels in dogs with HSA were significantly (P < 0.01) higher than in other dogs. High sensitivity (100%, 95% confidence interval 86-100%) and specificity (95%, 95% confidence interval 86-95%) for HSA diagnosis were obtained using a cut-off of 17 pg/mL according to receiver operating characteristic (ROC) curves (area under ROC curve 0.93). PPET1, ETA, VEGF and Hif1-α mRNA expression, measured by real-time PCR, were elevated in HSA compared with normal tissues. These findings suggest that elevated serum big ET-1 could be used as a diagnostic marker for canine HSA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25920760/