Peer-reviewed veterinary case report
Dog with testicular tumor spreading to the eye and treatment results
By Luis Gabriel Rivera-Calderón et al.·Published in Brazilian Journal of Veterinary Pathology·2020·College of Veterinary Medicine and Animal Husbandry, Universidad Antonio Nariño (UAN), Popayán, Cauca, Colombia., BR·View original on DOAJ →
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Original publication title: Bilateral canine seminoma with ocular metastasis: histochemical and immunohistochemical characterization
- Species:
- dog
Plain-English summary
A 10-year-old male dog was brought in because his left eye was bulging and he had lumps in both testicles. Due to the owner's limited resources and the dog's worsening eyesight, the veterinarian decided to remove the eye (enucleation) and perform castration. Tests showed that the lumps were cancerous cells (seminoma) that had spread to the eye. After the surgeries, the dog had the tumors removed, but the prognosis would depend on further treatment and monitoring for any signs of cancer recurrence.
People also search for: dog eye bulging treatment · dog testicular lumps cancer · seminoma in dogs treatment
Abstract
A 10-year old male dog was examined due to a buphthalmia in the left eye and a nodule in the two testicles. Due to the limited resources of the owner and loss of visual acuity of the patient, the enucleation and castration were chosen as treatment. Microscopic analysis of the testicular tissue revealed neoplastic germ cells. Morphologically, neoplastic cells were characterized by distinct cell borders, scarce and eosinophilic cytoplasm, large round nucleus, with thick chromatin and a prominent nucleolus. Binucleated and multinucleated neoplastic cells were also frequently observed. In 10 high power fields (400x), 62 typical and atypical mitosis were counted. Similar neoplastic cells were identified within the vessels of the retina, sclera and in the sub-epithelial conjunctive tissue of the eyelid. The neoplastic cells observed in the testicle and in the eye were positive for PAS. By immunochemistry technique was identified an intense immunostaining of the neoplastic cells for Vimentin and Ki-67 in both testicular and ocular tissue. While, discrete immunoreactivity was identified to c-KIT from the neoplastic cells in both organs. Based on morphological, histochemical and immunohistochemical analysis, it was possible to characterize the ocular lesion as seminoma metastasis.
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Search related cases →Original publication on DOAJ: https://doi.org/10.24070/bjvp.1983-0246.v13i1p57-61