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Peer-reviewed veterinary case report

Newborn horse with cystic eyes - what does it mean?

By Sano, Yuto et al.·Published in The Journal of veterinary medical science·2025·Department of Veterinary Pathology, Japan·View original on PubMed

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Original publication title: Bilateral congenital cystic eye with intraocular tissue differentiation in a horse.

Species:
horse

Plain-English summary

This case involves a 1-day-old horse that was found to have a rare eye condition called congenital cystic eye (CCE), which is a problem that happens during development and leads to cysts in the eye area. In this horse, the cysts were not just simple fluid-filled sacs; they actually contained some eye structures like the lens and optic nerve, which is unusual for this condition. The findings suggest that there can be different forms of CCE in horses, and this case adds to our understanding of how this condition can vary.

Abstract

Congenital cystic eye (CCE) is a rare congenital ocular disease, which has been suggested to be caused by problems with optic vesicle invagination. This is characterized by the formation of intraorbital cystic lesions lined by undifferentiated neuroepithelium. However, cases involving ocular structures with varying degrees of differentiation have also been reported as CCE in humans and animals. In horses, CCE have only been reported as a case presenting as neuroepithelial-lined cysts without the formation of ocular structures. This paper describes large bilateral intraorbital cysts in a 1-day-old horse. The histopathological findings revealed that the cysts were covered by neuroepithelium with formation of the lens, ciliary body, and optic nerve, and it was diagnosed as CCE. This report provides further variations of CCE in horses.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39567001/