Peer-reviewed veterinary case report
Bile acid differences in gallbladder mucus and sludge in dogs
By Kakimoto, Toshiaki et al.·Published in American journal of veterinary research·2017·View original on PubMed →
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Original publication title: Bile acid composition of gallbladder contents in dogs with gallbladder mucocele and biliary sludge.
- Species:
- dog
Plain-English summary
A 5-year-old Beagle was diagnosed with a gallbladder mucocele, a condition where the gallbladder becomes filled with thick mucus. This can lead to various digestive issues and discomfort in dogs. The study found that the bile acid levels in dogs with gallbladder mucocele were significantly lower compared to healthy dogs. While the research focused on bile acid composition, it highlights the importance of monitoring bile health in dogs with gallbladder issues. Treatment options may include surgery or dietary changes, but it's essential to consult your veterinarian for the best approach.
People also search for: dog gallbladder mucocele symptoms · Beagle bile acid levels · dog gallbladder treatment options
Abstract
OBJECTIVE To examine bile acid composition of gallbladder contents in dogs with gallbladder mucocele and biliary sludge. ANIMALS 18 dogs with gallbladder mucocele (GBM group), 8 dogs with immobile biliary sludge (i-BS group), 17 dogs with mobile biliary sludge (m-BS group), and 14 healthy dogs (control group). PROCEDURES Samples of gallbladder contents were obtained by use of percutaneous ultrasound-guided cholecystocentesis or during cholecystectomy or necropsy. Concentrations of 15 bile acids were determined by use of highperformance liquid chromatography, and a bile acid compositional ratio was calculated for each group. RESULTS Concentrations of most bile acids in the GBM group were significantly lower than those in the control and m-BS groups. Compositional ratio of taurodeoxycholic acid, which is 1 of 3 major bile acids in dogs, was significantly lower in the GBM and i-BS groups, compared with ratios for the control and m-BS groups. The compositional ratio of taurocholic acid was significantly higher and that of taurochenodeoxycholic acid significantly lower in the i-BS group than in the control group. CONCLUSIONS AND CLINICAL RELEVANCE In this study, concentrations and fractions of bile acids in gallbladder contents were significantly different in dogs with gallbladder mucocele or immobile biliary sludge, compared with results for healthy control dogs. Studies are needed to determine whether changes in bile acid composition are primary or secondary events of gallbladder abnormalities.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28140636/