Peer-reviewed veterinary case report
Biochemical markers of bone metabolism in animals: uses and limitations.
- Journal:
- Veterinary clinical pathology
- Year:
- 2003
- Authors:
- Allen, M J
- Affiliation:
- Department of Orthopedic Surgery · United States
Plain-English summary
This research looks at how we can better understand bone health in animals, especially when they are sick or injured. Traditionally, vets have used X-rays and other imaging techniques to see the bones, but these methods mainly show what has happened in the past. New tests that measure certain substances in the blood and urine can give us more immediate information about how bones are doing right now. The review discusses how these tests have been adapted for use in animals and what their limitations might be. Overall, the aim is to help veterinarians and researchers decide if these bone markers are useful for diagnosing and treating bone issues in pets.
Abstract
Routine assessment of the skeleton's response to disease and injury traditionally has consisted of plain-film radiography supplemented with advanced imaging techniques, such as computed tomography, magnetic resonance imaging, nuclear scintigraphy, and bone densitometry. Although these techniques provide increased sensitivity as compared with radiography, they still are limited by the fact that they can only document the net results of past skeletal activity. In contrast, serum and urinary biomarkers of bone formation and resorption provide near real-time information about bone cell activity. In this review, I describe the scientific rationale behind the use of these markers in humans and detail the efforts that have been made to adapt this technology to veterinary medicine and animal research. Commercial assay kits that are applicable to different animal species are described, and the potential limitations of the technology are discussed. The goal of this review is to provide clinical pathologists and researchers with the information needed to decide whether the use of bone markers is likely to be helpful and to select the most appropriate marker (or panel of markers) to answer a particular question.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/12966461/