Peer-reviewed veterinary case report
Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice.
- Journal:
- Digestive diseases and sciences
- Year:
- 2008
- Authors:
- Banerjee, Debashish et al.
- Affiliation:
- Department of Biochemistry · India
- Species:
- rodent
Abstract
Indomethacin caused maximum stomach ulceration in mice on the 3rd day, which was associated with reduction of plasma total antioxidant status (TAS), COX-1, COX-2, mucosal PGE(2), VEGF, and vWF, along with an increase in endostatin levels. Treatment with the phytochemical allylpyrocatechol (5 mg/kg, p.o. for 3 days) provided significant ulcer healing by reversing these biochemical parameters, as well as increasing the EGF expression more than that observed due to ulceration. Omeprazole (3 mg/kg, p.o. for 3 days) provided a similar healing by improving TAS and mucin levels, without significantly altering the other parameters.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18431645/