Peer-reviewed veterinary case report
Biofilm and antifungal response in yeasts from dog seborrheic
By Bumroongthai, K et al.·Published in Medical mycology·2016·Department of Veterinary Microbiology·View original on PubMed →
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Original publication title: Biofilm production and antifungal susceptibility of co-cultured Malassezia pachydermatis and Candida parapsilosis isolated from canine seborrheic dermatitis.
- Species:
- dog
Plain-English summary
A dog with seborrheic dermatitis (a skin condition causing flaky skin and irritation) was found to have two types of yeast, Malassezia pachydermatis and Candida parapsilosis, living on its skin. Researchers discovered that when these yeasts grow together, they form stronger biofilms, making them harder to treat with antifungal medications like itraconazole and ketoconazole. This means that dogs with this skin condition may not respond well to standard antifungal treatments due to the increased resistance caused by the mixed yeast cultures. Understanding this relationship can help veterinarians choose better treatment options for affected dogs.
People also search for: dog seborrheic dermatitis treatment · antifungal for dog skin infection · why is my dog’s skin flaky
Abstract
The yeasts Malassezia (M.) pachydermatis and Candida (C.) parapsilosis are often co-isolated in case of canine seborrhea dermatitis (SD) and also are emerging as opportunistic pathogens of immunocompromised human beings. Increased information about how their relationship results in biofilm production and an antifungal response would be useful to inform treatment and control. This study was designed to investigate biofilm production derived from co-culture of M. pachydermatis and C. parapsilosis from dog skin and to determine their in vitro antifungal susceptibility. We demonstrated that regardless of yeast strain or origin all single and dual cultures produced biofilms within 24 hours, and the greatest amount was present after 72 hours. Biofilm production from mixed cultures was greater than for single strains (P < .05). All sessile forms of the single and dual cultures were resistant to the tested antifungals itraconazole and ketoconazole, whereas planktonic forms were susceptible. The study suggests that dual cultures produce stronger biofilms that are likely to enhance persistence in skin lesions in dogs and result in greater resistance to antifungal treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26868903/