Peer-reviewed veterinary case report
Bioinformatic Discovery of a Cambialistic Monooxygenase.
- Year:
- 2024
- Authors:
- Liu C et al.
- Affiliation:
- Department of Chemistry · United States
Abstract
Dinuclear monooxygenases mediate challenging C-H bond oxidation reactions throughout nature. Many of these enzymes are presumed to exclusively utilize diiron cofactors. Herein we report the bioinformatic discovery of an orphan dinuclear monooxygenase that preferentially utilizes a heterobimetallic manganese-iron (Mn/Fe) cofactor to mediate an O<sub>2</sub>-dependent C-H bond hydroxylation reaction. Unlike the structurally similar Mn/Fe-dependent monooxygenase AibH2, the diiron form of this enzyme (SfbO) exhibits a nascent enzymatic activity. This behavior raises the possibility that many other dinuclear monooxygenases may be endowed with the capacity to harness cofactors with a variable metal content.
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Search related cases →Original publication: https://europepmc.org/article/MED/38198693