Peer-reviewed veterinary case report
Outcome for dogs with limb bone cancer treated by amputation
By Farese, James P et al.·Published in Veterinary surgery : VS·2009·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by amputation: a Veterinary Society of Surgical Oncology retrospective study.
- Species:
- dog
Plain-English summary
A group of 25 dogs diagnosed with appendicular chondrosarcoma (a type of bone cancer) underwent limb amputation as their only treatment. The study found that dogs with lower-grade tumors had a much better chance of survival compared to those with higher-grade tumors. On average, dogs with grade 1 tumors lived about 6 years after surgery, while those with grade 3 tumors had a median survival of less than a year. Overall, amputation alone can be an effective treatment for this type of cancer, especially for dogs with lower-grade tumors.
People also search for: dog bone cancer amputation · appendicular chondrosarcoma prognosis · dog cancer survival rates
Abstract
OBJECTIVE: To characterize biologic behavior, clinical outcome, and effect of histologic grade on prognosis for dogs with appendicular chondrosarcoma treated by amputation alone. STUDY DESIGN: Case series. ANIMALS: Dogs (n=25) with appendicular chondrosarcoma. METHODS: Medical records were searched to identify dogs with appendicular chondrosarcoma treated by limb amputation alone. Information recorded included signalment, anatomic location, radiographic appearance, and development of metastasis. Histopathologic diagnosis was confirmed and graded (1, 2, or 3). Survival curves were generated by the Kaplan-Meier method and the association between covariates (gender, age, weight, and tumor grade) and survival were evaluated using the univariate proportional hazards model. RESULTS: Histopathology slides were available for 25 dogs. Rates of pulmonary metastasis were as follows: grade 1-0%, grade 2-31%, and grade 3-50%. Overall median survival time (MST) was 979 days. Age, weight, and sex were not significantly associated with survival (P=.16; .33; and .31, respectively). Survival was significantly associated with tumor grade (P=.008), with dogs with tumor grade of 1, 2, and 3 having MSTs of 6, 2.7, and 0.9 years, respectively. CONCLUSION: Canine appendicular chondrosarcoma can be treated effectively with amputation alone. Low to intermediate grade chondrosarcoma has a good prognosis, whereas high-grade tumors appear to behave aggressively. CLINICAL RELEVANCE: The overall prognosis for appendicular chondrosarcoma is better than that of appendicular osteosarcoma treated by amputation alone or in combination with chemotherapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20017847/