Peer-reviewed veterinary case report
Variability of heart disease blood test in healthy dogs and dogs
By Winter, Randolph L et al.·Published in Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2017·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Biologic variability of N-terminal pro-brain natriuretic peptide in healthy dogs and dogs with myxomatous mitral valve disease.
- Species:
- dog
Plain-English summary
A group of dogs with myxomatous mitral valve disease (MMVD), a common heart condition, had their levels of a specific heart-related protein (NTproBNP) measured to see how they varied over time. The study included 28 dogs with MMVD and 10 healthy dogs. It found that the NTproBNP levels showed different patterns of variability between healthy dogs and those with heart disease. This information can help veterinarians monitor heart health in dogs by tracking changes in NTproBNP levels over time, which could indicate how the disease is progressing.
People also search for: dog heart disease symptoms · NTproBNP levels in dogs · myxomatous mitral valve disease treatment
Abstract
INTRODUCTION: To determine the biologic variability of N-terminal pro-brain natriuretic peptide (NTproBNP) in healthy dogs and dogs with various stages of myxomatous mitral valve disease (MMVD). ANIMALS: Thirty-eight privately owned dogs: 28 with MMVD and 10 healthy controls. MATERIALS AND METHODS: Prospective clinical study with comprehensive evaluation used to group dogs as healthy or into three stages of MMVD based on current guidelines. NTproBNP was measured hourly, daily, and weekly. For each group, analytical (CV), within-subject (CV), and between-subject (CV) coefficients of variability were calculated in addition to percent critical change value (CCV) and index of individuality (IoI). RESULTS: For healthy dogs, calculated NTproBNP values were: CV = 4.2%; CV = 25.2%; CV = 49.3%; IoI = 0.52, and CCV = 70.8%. For dogs with MMVD, calculated NTproBNP values were: CV = 6.2%; CV = 20.0%; CV = 61.3%; IoI = 0.34, and CCV = 58.2%. CONCLUSIONS: Biologic variability affects NTproBNP concentrations in healthy dogs and dogs with MMVD. Monitoring serial individual changes in NTproBNP may be clinically relevant in addition to using population-based reference ranges to determine changes in disease status.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28111138/