Peer-reviewed veterinary case report
Oral and muzzle mast cell tumors in 44 dogs survival study
By Hillman, Lorin A et al.·Published in Journal of the American Veterinary Medical Association·2010·Department of Veterinary Clinical Medicine, United States·View original on PubMed →
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Original publication title: Biological behavior of oral and perioral mast cell tumors in dogs: 44 cases (1996-2006).
- Species:
- dog
Plain-English summary
A group of 44 dogs with mast cell tumors (MCTs) in the mouth or around the muzzle were studied to understand their outcomes. Many of these dogs had lymph node metastasis, which is when the cancer spreads to nearby lymph nodes, and this was linked to a shorter survival time. On average, dogs without lymph node involvement lived much longer than those with it. However, with appropriate treatment, dogs could still achieve a good quality of life and longer survival times, even if they had more advanced disease.
People also search for: dog mouth tumor treatment · mast cell tumor prognosis in dogs · dog cancer lymph node involvement
Abstract
OBJECTIVE: To describe clinical outcome of dogs with mast cell tumors (MCTs) arising from the oral mucosa, oral mucocutaneous junction, or perioral region of the muzzle and evaluate the potential role of the chemokine receptor type 7 (CCR7) in the biological behavior of these tumors. DESIGN: Retrospective case series. ANIMALS: 44 dogs with MCTs of the oral mucosa (n=14), oral mucocutaneous junction (19), or perioral region of the muzzle (11). PROCEDURES: Medical records were reviewed for information on signalment, regional metastasis, treatments, cause of death, and survival time. Twenty of the 44 cases had stored histologic samples available for immunohistochemical staining for CCR7 RESULTS: For all dogs, median survival time was 52 months. Twenty-six (59%) dogs had regional lymph node metastasis on admission. Median survival time for dogs with lymph node metastasis was 14 months, whereas median survival time was not reached for dogs without lymph node metastasis. Intensity of staining for CCR7 was not significantly associated with the presence of regional lymph node metastasis or survival time. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that in dogs with MCTs arising from the oral mucosa, oral mucocutaneous junction, or perioral region of the muzzle, the presence of regional lymph node metastasis at the time of diagnosis was a negative prognostic factor. However, prolonged survival times could be achieved with treatment. In addition, CCR7 expression in the primary tumor was not significantly associated with the presence of regional lymph node metastasis or survival time.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20946081/