Peer-reviewed veterinary case report
Biology of Porcine Parvovirus (Ungulate parvovirus 1).
- Journal:
- Viruses
- Year:
- 2017
- Authors:
- Mészáros, István et al.
- Affiliation:
- Institute for Veterinary Medical Research
Plain-English summary
Porcine parvovirus (PPV) is a virus that can cause infertility in pigs, which is a big concern for pig farmers. It was previously believed that there wasn't much variation in the virus, making it easier to control with vaccines. However, recent observations have shown that there are new strains of the virus that are more diverse and some of these strains are not effectively targeted by the vaccines that were developed for older versions of the virus. This has led to new research that has improved our understanding of how PPV works and how it affects pigs. Overall, the findings suggest that we need to rethink how we approach vaccination and treatment for this virus.
Abstract
Porcine parvovirus (PPV) is among the most important infectious agents causing infertility in pigs. Until recently, it was thought that the virus had low genetic variance, and that prevention of its harmful effect on pig fertility could be well-controlled by vaccination. However, at the beginning of the third millennium, field observations raised concerns about the effectiveness of the available vaccines against newly emerging strains. Subsequent investigations radically changed our view on the evolution and immunology of PPV, revealing that the virus is much more diverse than it was earlier anticipated, and that some of the "new" highly virulent isolates cannot be neutralized effectively by antisera raised against "old" PPV vaccine strains. These findings revitalized PPV research that led to significant advancements in the understanding of early and late viral processes during PPV infection. Our review summarizes the recent results of PPV research and aims to give a comprehensive update on the present understanding of PPV biology.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29261104/