Biosynthesized Silver Nanoparticles Modulate Inflammation in a Palatine Wound Model.

Abstract

OBJECTIVES: This study aimed to compare the effects of silver nanoparticles (AgNPs) synthesized with Curcumin (Curcuma longa L.) or Açai (Euterpe oleracea) versus a commercial treatment and photobiomodulation in rat palatal wounds. METHODS: In vitro cell viability tests assessed nanoparticle toxicity. The animals were initially anesthetized, and circular lesions were created in the palatine mucosa using a 4 mm/diameter punch. The first treatment session commenced 24 h after the injury and continued daily for 5 days. Twenty-four hours after the final treatment, the animals were euthanized, and the palatal mucosa tissue was collected for histological and biochemical analyses. RESULTS: AgNPs-Cur significantly reduced pro-inflammatory cytokines and oxidant markers, increased anti-inflammatory cytokines, the wound contraction rate, and the collagen area, and reduced the inflammatory infiltrate compared to the controls. CONCLUSION: The therapies effectively aided inflammation resolution and accelerated tissue repair. This study highlights potential cost-effective and efficient alternatives for oral and palatal mucosa wound healing, improving upon standard commercial treatments.