Peer-reviewed veterinary case report
Biotic concerns in generating molecular diagnosis matrixes for 4 avian viruses with emphasis on Marek's disease virus.
- Journal:
- Journal of virological methods
- Year:
- 2019
- Authors:
- Davidson, Irit
- Affiliation:
- Kimron Veterinary Institute
- Species:
- bird
Plain-English summary
This review discusses how advancements in testing for bird viruses, particularly Marek's disease virus, can improve diagnosis in poultry. It highlights the importance of considering various factors when testing, such as the type of sample taken, the timing of the sample, and the possibility of multiple viruses being present at the same time. By paying attention to these details and using advanced testing methods, veterinarians can provide more accurate and timely diagnoses. This approach could greatly benefit the poultry industry by helping to manage and control these diseases more effectively.
Abstract
The great advance in the field of diagnosis of avian viruses is reflecting the highly sophisticated molecular assays of the human and general virology in providing highly sensitive and fast methods of diagnosis. The present review will discuss the biotic factors and the complexities that became evident with the evolution of the novel molecular diagnostic assays with emphasis on 4 avian viruses, chicken anemia, infectious laryngotracheitis, turkey meningoencephalitis, but mainly on Marek's disease virus. To create a biologically meaningful diagnosis, attention should be dedicated to various biotic factors and not only of the diagnostic assay. Included among the important factors are, (a) the sample examined and the sampling strategy, (b) the outcomes of the pathogen amplification ex vivo, (c) the sampling time and its reflection on the disease diagnosis, (d) the impact of simultaneous multiple virus-infections regarding the ability to demonstrate all pathogens and inter- and intra-interactions between the pathogens. A concerted consideration of the relevant factors and the use of advanced molecular diagnostic assay would yield biologically significant diagnosis in real-time that would beneficiate the poultry industry.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31351169/