Peer-reviewed veterinary case report
Oxidative stress markers in cats with blocked urethra
By Quintavalla, Fausto et al.Ā·Published in BMC veterinary researchĀ·2024Ā·Department of Veterinary Sciences, ItalyĀ·View original on PubMed ā
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Original publication title: Blood plasma and urinary biomarkers of oxidative stress in cats with urethral obstruction.
- Species:
- cat
Plain-English summary
A 5-year-old male cat with urethral obstruction (a blockage in the urinary tract) was studied to understand the effects of this condition on oxidative stress in the body. The researchers found that the cat's condition led to increased oxidative stress, which is an imbalance between free radicals and antioxidants in the body. While some markers in the urine showed changes due to the obstruction, they indicated that the lower urinary tract wasn't damaged. The study suggests that monitoring oxidative stress levels could help assess the severity of urethral obstruction in cats.
People also search for: cat urethral obstruction symptoms Ā· cat urinary blockage treatment Ā· feline idiopathic cystitis causes
Abstract
BACKGROUND: This study aimed to investigate variations of the oxidative status in cats affected by urethral obstruction (UO) under Feline Idiopathic Cystitis (FIC) and Bacterial Cystitis (BC), in comparison with a group of healthy subjects. In both groups, the levels of several markers (either direct or indirect) indicative of the oxidative attack and of the antioxidant response were analyzed on plasma and urine samples. In particular, the plasma samples were evaluated for nitric oxide (NO), hydroperoxides derived by reactive oxygen activity (d-ROMs test), superoxide anion (O), glutathione peroxidase activity (GPx), superoxide dismutase activity (SOD), and ferric reducing antioxidant power (FRAP test); while on urine the levels of NO, d-ROMs, FRAP, SOD, malondialdehyde (MDA) and 8-hydroxydeoxyguanosine (8-OHdG) were measured. Urine of UO patients was also subjected to urine-culture test. RESULTS: The analytical data on plasma showed that UO, independently of the FIC or BC etiology, induced the insurgence of oxidative stress conditions at the systemic level. In the urine of the UO patients, except for SOD that increased, the markers of redox status were markedly decreased due probably their compromised filtration, thus suggesting involvement of renal function (assessed also by the high levels of plasma creatinine and proteinuria) with no oxidative damage of the lower urinary tract. Moreover, the adoption of a novel oxidative stress index' (OSI) allowed to establish, by means of a numerical value, the different degrees of oxidative stress conditions for single UO patients, both in terms of oxidative attack and antioxidant response. CONCLUSIONS: Feline urethral obstruction, induced by Idiopathic Cystitis and Bacterial Cystitis, causes oxidative stress conditions at the systemic level that do not interest the lower urinary tract. Despite to the high variability of the profiles of oxidative stress indexes both in healthy and UO patients, the determination of OSI made possible the evaluation of their single degrees of oxidative stress. Possibly the results of this investigation can be compared with those of correspondent pathologies both in humans and in other animal species.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38678221/