Peer-reviewed veterinary case report
Blood-to-saliva glucose time lag in sedated healthy dogs.
- Journal:
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Year:
- 2021
- Authors:
- Ioannou, Antonia et al.
- Affiliation:
- Department of Veterinary Clinical Medicine · United States
- Species:
- dog
Plain-English summary
In a study involving six healthy dogs, researchers looked at how long it takes for glucose levels in the blood to show up in saliva after giving a dose of dextrose, a type of sugar. They found that saliva production averaged about 10.3 microliters per kilogram per minute, and there was a significant difference in glucose levels between blood and saliva. The time it took for blood glucose levels to appear in saliva was found to be between 30 to 40 minutes. This information could help improve how diabetes is managed in dogs by using saliva for glucose monitoring.
Abstract
The management of diabetes mellitus mandates measurement of blood glucose. Saliva offers an alternative to blood sampling, but measurement of the salivary glucose concentration is difficult, and the blood-to-saliva glucose time lag is uncertain. We aimed to determine the serum-saliva glucose time lag in the saliva of healthy dogs. The combined duct of the mandibular and sublingual salivary glands of 6 dogs was cannulated to collect saliva and prevent glucose degradation by oral bacteria. Following a 0.25 g/kg IV bolus of dextrose, paired serum-saliva samples were collected at baseline and in twelve 5-min blocks over 60 min. Serum and salivary glucose levels were analyzed with a linear mixed model for repeated measures with a compound symmetry error structure. Mean (±SD) saliva production was 10.3 ± 2.9 µL/kg/min, and the area under the curve (AUC)ratio was 0.006, which highlights the magnitude of the large difference in glucose concentration between the 2 compartments. The serum-saliva glucose time lag was 30-40 min.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/34301161/