Peer-reviewed veterinary case report
BMAA neurotoxicity in Drosophila.
- Journal:
- Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
- Year:
- 2009
- Authors:
- Zhou, Xianchong et al.
- Affiliation:
- Department of Molecular and Cellular Pharmacology · United States
Abstract
We report the establishment of an in vivo model using the fruit fly Drosophila melanogaster to investigate the toxic effects of L-BMAA. We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19929734/