Peer-reviewed veterinary case report
Bone marrow cells boost bone growth with OP-1 in dog femur defects
By Takigami, Hidetake et al.·Published in Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2007·Department of Biomedical Engineering, United States·View original on PubMed →
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Original publication title: Bone formation following OP-1 implantation is improved by addition of autogenous bone marrow cells in a canine femur defect model.
- Species:
- dog
Plain-English summary
A group of seven dogs with bone defects in their thigh bones received an implant called Osteogenic Protein-1 (OP-1) to help stimulate new bone growth. Some dogs had the OP-1 combined with their own bone marrow cells, while others had it with clotted blood. The dogs that received the bone marrow showed more new bone formation after four weeks compared to those that did not. This suggests that using bone marrow can improve the effectiveness of OP-1 in promoting bone healing.
People also search for: dog bone healing treatment · OP-1 for dog bone repair · canine bone marrow transplant benefits
Abstract
Osteogenic Protein-1 (OP-1, BMP-7) acts locally on connective tissue progenitors (CTPs) to induce bone formation. The response to OP-1 and similar agents is potentially limited by the number of local CTPs. This study tested the hypothesis that supplementing local CTPs using autogenous bone marrow will enhance bone formation at an OP-1 implant. Four 1.0-cm diameter unicortical cylindrical defects in the left proximal femur were grafted in each of seven dogs. Radial ingrowth of new bone formation was assessed at 4 weeks using micro CT. The OP-1 (3.5 mg rhOP-1 in 1 g bovine collagen I matrix) was implanted in each site combined with either clotted blood or aspirated bone marrow (BM). Bone formation was increased in the group augmented with transplanted marrow. These data suggest that increasing the local population of cells and CTPs using aspirated bone marrow can enhance the performance of OP-1, but may not eliminate the effects of site variation on the response to OP-1 and similar agents. The canine multiple femoral defect model defined in this study is well suited to quantitatively evaluate strategies for augmenting bone repair using local cell targeting and cell transplantation strategies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17551968/