Peer-reviewed veterinary case report
Bone lesions in three dogs with multiple myeloma
By Maeda, H et al.·Published in Zentralblatt fur Veterinarmedizin. Reihe A·1993·Research Institute of Drug Safety, Japan·View original on PubMed →
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Original publication title: Bone lesions of multiple myeloma in three dogs.
- Species:
- dog
Plain-English summary
Three dogs were diagnosed with multiple myeloma, a type of cancer that affects the bone marrow. They showed symptoms like bone lesions and, in one case, protein in the urine. X-rays revealed serious damage to their bones, particularly in areas where blood cells are made. The dogs had small holes in their bones that could grow larger over time, but interestingly, these changes didn't always mean there were tumor cells present. Treatment details weren't specified, but understanding these bone lesions can help vets manage the condition better.
People also search for: dog multiple myeloma symptoms · dog bone lesions treatment · what is Bence-Jones proteinuria in dogs
Abstract
Three cases of canine multiple myeloma that showed monoclonal IgA gammopathy and bone lesions were examined. One dog was associated with Bence-Jones proteinuria as well. Radiographic examination revealed extensive skeletal involvement of flat bones such as scapula, pelvic bone, costa, and epiphysis of long bones where the hematopoiesis was active throughout the life. Histopathologically, small osteolytic lesions occurred from periosteum and Haversian canal as well as endosteum, and larger lesions were formed by gradual expansion or fusion of small lesions. Osteolytic lesions did not necessarily involve tumor growth, explaining the inconsistent confirmation of tumor cells in biopsy specimens for diagnosis of multiple myeloma and suggesting the possible mechanism for osteolysis by some other humoral factors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8212953/