Peer-reviewed veterinary case report
Cat developed bone marrow failure after griseofulvin treatment
By Rottman, J B et al.·Published in Journal of the American Veterinary Medical Association·1991·Department of Companion Animal·View original on PubMed →
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Original publication title: Bone marrow hypoplasia in a cat treated with griseofulvin.
- Species:
- cat
Plain-English summary
An 8-year-old domestic shorthair cat developed severe depression, vomiting, and fever three weeks after starting treatment with griseofulvin for a skin infection. During the vet visit, the cat showed signs of visual impairment, heart murmurs, and hair loss, and blood tests revealed a dangerous drop in blood cell levels. Unfortunately, the bone marrow was found to be severely underdeveloped, leading to a diagnosis of griseofulvin toxicosis. Despite attempts to treat the condition, it was too severe, and the cat was euthanized.
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Abstract
Three weeks after initiation of griseofulvin treatment for dermatophytosis (40 mg/kg of body weight, q 12 h), an 8-yr-old domestic shorthair cat developed depression, vomiting, and pyrexia. Abnormalities found during physical examination included bilateral mydriasis, visual impairment, grade-II/V systolic murmur and multiple areas of alopecia. The cat was pancytopenic; serum biochemical abnormalities included hyperbilirubinemia, hyperglycemia, hyponatremia, and hypokalemia, and urinalysis revealed proteinuria, glycosuria, and bilirubinuria. Examination of a bone marrow aspirate revealed profound hypoplasia of all precursors. Griseofulvin toxicosis was diagnosed on the basis of the temporal relationship of drug administration with onset of clinical, hematologic, and biochemical abnormalities and failure to identify an infective or neoplastic cause for the bone marrow hypoplasia. The condition was refractory to treatment and the cat was euthanatized. Pathologic changes in the bone marrow were consistent with severe hypoplasia of all bone marrow precursors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/2010336/