Peer-reviewed veterinary case report
Boosting NKCC1 in the choroid plexus: From CSF clearance to a potential therapy for posthemorrhagic hydrocephalus.
- Journal:
- Neuron
- Year:
- 2023
- Authors:
- Jeong, Inyoung & Jurisch-Yaksi, Nathalie
- Affiliation:
- Department of Clinical and Molecular Medicine
Abstract
In this issue of Neuron, Sadegh et al.identify a novel potential therapeutical target for posthemorrhagic hydrocephalus (PHH). The authors identified that overexpression of Na-K-2Cl cotransporter-1 (NKCC1) in the choroid plexus relieves ventriculomegaly and enhances cerebrospinal fluid (CSF) clearance in improved PHH mouse models.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37201502/