Peer-reviewed veterinary case report
Borna disease causing brain disorder in a 3-year-old dog in Japan
By Okamoto, M et al.·Published in Journal of comparative pathology·2002·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Borna disease in a dog in Japan.
- Species:
- dog
Plain-English summary
A 3-year-old male Welsh corgi in Japan was diagnosed with Borna disease after showing severe and worsening neurological symptoms. This condition affects the central nervous system and can lead to serious issues like inflammation in the brain and spinal cord. The diagnosis was confirmed through tests that identified the presence of the Borna virus in the dog's brain tissue. Unfortunately, the abstract does not provide information on the treatment or outcome for this dog.
People also search for: dog neurological symptoms · Welsh corgi Borna disease · dog brain infection treatment
Abstract
Borna disease (BD) was diagnosed in a 3-year-old male Welsh corgi suffering from a severe and acute progressive disorder of the central nervous system. Histopathologically, neuronal lesions were characterized by a non-suppurative encephalomyelitis dominated by large perivascular cuffs consisting of lymphocytes, macrophages and plasma cells; also present were inflammatory cell infiltrates in the neural parenchyma, neuronophagia and focal gliosis. Strong immunolabelling with BD virus (BDV) p40 antibody was diffusely distributed in the cytoplasm of small and large neurons in areas of the brain with and without inflammatory changes, and also in the spinal cord. Positive hybridization signals with BDV p40 sense and antisense riboprobes were seen in the nucleus and cytoplasm of the neurons throughout the whole brain and spinal cord. BDV p24 RNA in formalin-fixed brain tissue was detected by reverse transcriptase (RT)-nested polymerase chain reaction (PCR). BDV p24 RNA-positive signals were detected in the temporal lobe. This is the first report of spontaneous canine BD in Japan.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12056780/