Peer-reviewed veterinary case report
Boron neutron capture therapy (BNCT) as a new approach for clear cell sarcoma (CCS) treatment: Trial using a lung metastasis model of CCS.
- Journal:
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
- Year:
- 2015
- Authors:
- Andoh, Tooru et al.
- Affiliation:
- Faculty of Pharmaceutical Sciences · Japan
Abstract
Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In the present study, we established a lung metastasis animal model of CCS and investigated the therapeutic effect of boron neutron capture therapy (BNCT) using p-borono-L-phenylalanine (L-BPA). Biodistribution data revealed tumor-selective accumulation of (10)B. Unlike conventional gamma-ray irradiation, BNCT significantly suppressed tumor growth without damaging normal tissues, suggesting that it may be a potential new therapeutic option to treat CCS lung metastases.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26337135/