Peer-reviewed veterinary case report
Oleander extract boosts dog skin allergy immune response better than
By Fossum, Theresa W et al.·Published in American journal of veterinary research·2024·Phoenix Animal Wellness·View original on PubMed →
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Original publication title: Botanical oleander extract and oleandrin have superior effects on innate immune functions pertaining to dermal allergic reactions in canine cells when compared to oclacitinib.
- Species:
- dog
Plain-English summary
A study found that oleander extract and oleandrin may be more effective than a common allergy medication, oclacitinib, for treating skin allergies in dogs. These substances helped reduce inflammation and regulate immune responses in dog skin cells, which is important for managing conditions like atopic dermatitis. While oclacitinib did show some benefits, it was less effective overall and sometimes even increased certain inflammatory markers. This suggests that oleander extract and oleandrin could be promising options for dogs suffering from skin allergies, but more research is needed to confirm their effectiveness in real-life cases.
People also search for: dog skin allergies treatment · oleander extract for dogs · oclacitinib side effects in dogs
Abstract
OBJECTIVE: To perform testing for cytokines involved in dermal inflammatory reactions and to document and compare the effects of an oleander extract (OE), oleandrin, and oclacitinib on biomarkers relevant to allergic reactions. The effects of these compounds under inflamed culture conditions are of direct importance to the treatment of canine atopic dermatitis. METHODS: Testing involved primary canine dermal fibroblasts and the canine DH82 macrophage cell line; both cell types are important for initiating, regulating, and resolving dermal allergic reactions via cytokine communication. RESULTS: Under inflamed conditions, OE and oleandrin downregulated key cytokines secreted by canine dermal fibroblasts and the DH82 macrophage cell line; all of which are treatment targets in dermatitis. In the DH82 macrophage cultures, the most noteworthy reductions involved IL-6, IL-12/IL-23p40, interferon-γ, tumor necrosis factor-α, VEGF, and nerve growth factor-β. Oclacitinib triggered reductions of some cytokines involved in allergic reactions, including TGF-β1, IL-12/IL-23p40, and tumor necrosis factor-α; however, these reductions were less robust than the reductions triggered by OE and oleandrin and accompanied by increases in other cytokines involved in dermal inflammation, including IL-6, interferon-γ, and nerve growth factor-β. In cultures of primary dermal fibroblasts, OE and oleandrin reduced the levels of IL-8 and monocyte chemoattractant protein-1, whereas oclacitinib had little or no effect. CONCLUSIONS: Oleander extract and oleandrin directly modulate immune responses under inflamed conditions. Moreover, OE and oleandrin appear to provide a more beneficial overall cytokine regulation than oclacitinib under inflamed culture conditions. CLINICAL RELEVANCE: These results suggest that OE and oleandrin are efficacious agents to treat canine atopic dermatitis. Future studies should evaluate the efficacy of these compounds in dogs affected by atopic dermatitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39362280/