Brain-Derived Neurotrophic Factor Cancels the Cardioprotective Effect of Interleukin-2 in a Model of Systemic Inflammatory Response in Rats.

Abstract

Contradictory data about the cardioprotective and neuroprotective effects of IL-2 and BDNF and our own data on specific differences in myocardial resistance to ischemia-reperfusion after administration of exogenous IL-2 and BDNF prompted us to study the effect of combined administration of these two agents on the size of the necrosis zone in the isolated heart of rats with modeled systemic inflammatory response syndrome (SIRS). In the SIRS group, a significant increase in most proinflammatory markers in the blood and a 65% increase in the area of myocardial necrosis after ischemia-reperfusion in comparison with the control were observed. After IL-2 administration, the necrosis zone was significantly smaller than in rats with SIRS and the level of most analytes decreased. Combined administration of IL-2 and BDNF abolished the decrease in the size of the necrosis zone compared to that in rats with SIRS.