Peer-reviewed veterinary case report
Brain-derived neurotrophic factor helps bone regrow around implants
By Kono, Shoko et al.·Published in International journal of implant dentistry·2024·Department of Periodontal Medicine, Japan·View original on PubMed →
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Original publication title: Brain-derived neurotrophic factor promotes bone regeneration in a canine model of peri-implantitis.
- Species:
- dog
Plain-English summary
A group of dogs that had their premolars removed and dental implants placed were treated for bone loss due to peri-implantitis (an infection around dental implants). Some dogs received no treatment, while others had a cleaning procedure, and some were treated with a special combination of brain-derived neurotrophic factor (BDNF) and hyaluronic acid. The dogs that received the BDNF/HMW-HA treatment showed significant improvement in bone levels around the implants after 12 weeks, with less inflammation and no signs of infection. This suggests that this treatment could help regenerate bone in dogs with similar dental issues.
People also search for: dog dental implant infection treatment · peri-implantitis in dogs · BDNF for dog bone regeneration
Abstract
PURPOSE: The present study aims to determine whether the brain-derived neurotrophic factor (BDNF)/high-molecular-weight hyaluronic acid (HMW-HA) complex could regenerate bone around implants lost due to peri-implantitis. METHODS: Dogs had their three premolars extracted, and three implants were placed on each side. After osseointegration, 3-0 silk threads were ligated around the healing abutment for 12 weeks. Implants were classified into four groups-no treatment (control group), non-surgical debridement (debridement group), non-surgical debridement with application of HMW-HA (HMW-HA group), and non-surgical debridement with application of BDNF/HMW-HA complex (BDNF/HMW-HA group). Probing pocket depth (PPD), attachment level (AL), and bleeding on probing (BOP) were recorded before and 12 weeks after each treatment. Standardized intraoral radiographs were obtained, and histological analysis was conducted. RESULTS: The bone level on radiographs significantly improved (median -0.15 mm, IQR -0.31 to 0.10) only in the BDNF/HMW-HA group, while changes in PPD and AL were similar to those in other groups. The BOP positivity rate decreased in the debridement and BDNF/HMW-HA groups. Unlike images of the other groups, histological images of the BDNF/HMW-HA group showed no epithelial migration toward the tip of the implant. Inflammatory cell infiltration was reduced compared with that in the other groups. New bone was observed around the implants only in the BDNF/HMW-HA group. CONCLUSIONS: The BDNF/HMW-HA complex appears to promote bone regeneration when combined with non-surgical debridement for peri-implantitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39589662/