Peer-reviewed veterinary case report
Brain tumors from uterine cancer in two dogs
By de Sousa, Isabelle Vieira et al.·Published in Veterinary research communications·2025·Graduate Program in Animal Health and Science, Brazil·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Brain metastases from endometrial carcinoma in two dogs.
- Species:
- dog
Plain-English summary
A 7-year-old mixed-breed dog and an 11-year-old Poodle were both brought in with severe symptoms, including bloody or purulent discharge, lethargy, and difficulty breathing. Sadly, both dogs passed away during emergency treatment. A necropsy revealed that their endometrial carcinoma (a type of cancer originating in the uterus) had spread to the brain and other organs, which likely caused their acute neurological symptoms. This highlights the need for veterinarians to consider endometrial carcinoma when dogs show signs of serious illness with neurological involvement.
People also search for: dog cancer symptoms · why is my dog lethargic · dog with bloody discharge · endometrial carcinoma in dogs · dog brain metastasis treatment
Abstract
Endometrial carcinoma is an uncommon epithelial neoplasm in dogs. This study reports two cases of endometrial carcinomas with brain metastasis in a 7-year-old mixed-breed dog with bloody vulvar discharge, prostration, lethargy, and hyperextension of all four limbs, and an 11-year-old Poodle with purulent vulvar discharge, dyspnea, lateral recumbency, limb stiffness, and epistaxis. Both dogs died during emergency care. Necropsy revealed multiple metastatic nodules in several organs, including the brain. Histopathology showed proliferative endometrial glands with atypical cuboidal-to-columnar cells, while immunohistochemistry confirmed epithelial origin (AE1/AE3-positive). These findings underscore the importance of including endometrial carcinoma in the differential diagnosis of disseminated metastatic disease associated with acute neurological conditions in dogs.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41240137/