Peer-reviewed veterinary case report
Breathing down resistance: Tackling hypoxia to overcome immunotherapy barriers in lung cancer.
- Journal:
- The Journal of experimental medicine
- Year:
- 2025
- Authors:
- Chen, Huanhuan Joyce
- Affiliation:
- The Pritzker School of Molecular Engineering · United States
Abstract
In this issue of JEM, Robles-Oteiza et al. (https://doi.org/10.1084/jem.20231106) present compelling evidence linking tumor hypoxia to acquired resistance mechanisms in non-small cell lung cancer (NSCLC) treatments involving immune checkpoint inhibitors (ICIs). Their research advocates targeting these hypoxic tumor regions with hypoxia-activated pro-drugs like TH-302, which may substantially delay the onset of resistance and herald a significant advancement in cancer therapy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39585349/