Peer-reviewed veterinary case report
Broad-spectrum activity of a novel antibiotic peptide against multidrug-resistant veterinary isolates.
- Journal:
- Veterinary journal (London, England : 1997)
- Year:
- 2013
- Authors:
- Cabassi, Clotilde Silvia et al.
- Affiliation:
- Dipartimento di Scienze Medico-Veterinarie · Italy
- Species:
- dog
Abstract
The emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) bacteria has become a medical and veterinary problem. Antimicrobial peptides (AMPs) show potential to overcome antibiotic resistance and could be used therapeutically. A novel AMP (AMP2041) was developed in silico and its microbiocidal activity against MDR clinical strains isolated from cattle (n=6), dogs (n=8), and pigs (n=20) was evaluated. AMP2041 showed strong antimicrobial activity against all Gram-positive and Gram-negative MDR clinical strains tested. Within 20 min of incubation, there was complete killing of Pseudomonas aeruginosa ATCC 27953 and a 90% reduction of colony count for Escherichia coli ATCC 25922. For Staphylococcus aureus ATCC 25923, a 90% reduction of colony count was observed within 120 min of incubation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24084036/