Peer-reviewed veterinary case report
Brucella abortus lysed cells protect Beagles from infection
By Kim, Won Kyong et al.·Published in Pathogens and disease·2018·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Brucella abortus lysed cells using GI24 induce robust immune response and provide effective protection in Beagles.
- Species:
- dog
Plain-English summary
A group of Beagles was tested to see if a new vaccine made from killed Brucella abortus bacteria could protect them from brucellosis, a serious infection. One group of dogs received the vaccine, while another group received a placebo. After being exposed to the bacteria, the vaccinated dogs showed strong immune responses and no signs of infection, while the unvaccinated dogs had detectable bacteria in their bodies. This study suggests that the new vaccine could be an effective way to protect dogs from brucellosis.
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Abstract
The aim of the present study is to estimate the protective efficacy of Brucella abortus lysed cells by GI24 against brucellosis in Beagles. Group A was subcutaneously (sc) immunized with sterile phosphate-buffered saline, and group B was sc immunized with approximately 3 × 109 of the lysed cells. Brucella-LPS-specific serum IgG titers and IL-4, TNF-α and IFN-γ concentrations were investigated by enzyme linked immunosorbent assay. All dogs were intraconjunctivally challenged with B. abortus strain 544 at 6 weeks post-prime immunization. The serum IgG titers were considerably higher in group B than in group A. The levels of IL-4, TNF-α and IFN-γ in group B than in group A were significantly higher. Following challenge, no challenge strain was observed from all tissues of three dogs of group B. However, challenge strain was detected from spleen, uterus (except one Beagle) and inguinal and retropharyngeal lymph nodes of all group A Beagles. The results of this study demonstrated that sc immunization with the lysed cells induced robust antibody and cell-mediated immune responses in Beagles. The lysed cells also conferred protection against infection with B. abortus. These results suggest that sc immunization with B. abortus lysed cells by GI24 is a good vaccine candidate against brucellosis in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29272378/