Peer-reviewed veterinary case report
Dog with blistering skin from systemic lupus erythematosus type I
By Olivry, T et al.·Published in The Veterinary record·1999·Department of Companion Animal and Special Species, United States·View original on PubMed →
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Original publication title: Bullous systemic lupus erythematosus (type I) in a dog.
- Species:
- dog
Plain-English summary
A dog was diagnosed with bullous systemic lupus erythematosus (BSLE), a serious autoimmune condition that caused painful blisters and sores on its skin. The dog showed signs of skin lesions that were vesicular and ulcerative, leading the veterinarian to perform tests that confirmed the diagnosis. Treatment options for BSLE can vary, but managing the autoimmune response is crucial. If your dog is showing similar skin issues, it’s important to consult your veterinarian for a proper diagnosis and treatment plan.
People also search for: dog skin blisters treatment · autoimmune skin disease in dogs · bullous lupus in dogs
Abstract
In human patients with systemic lupus erythematosus, cutaneous subepidermal blistering can occur because of the production of antibodies specific for basement membrane antigens. This condition is referred to as bullous systemic lupus erythematosus (BSLE). A dog was diagnosed with BSLE because it fulfilled the following criteria: (i) a diagnosis of systemic lupus erythematosus by standard methods; (ii) an acquired, vesicular, erosive and ulcerative eruption; (iii) microscopical subepidermal vesicles with neutrophil-predominant inflammation at the dermo-epidermal junction; (iv) deposition of IgG at the epidermal basement membrane zone; and (v) circulating IgG autoantibodies against type VII collagen. Anti-collagen VII type I-BSLE therefore needs to be considered as a possible differential diagnosis for canine autoimmune subepidermal blistering diseases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10466774/