Butorphanol with oxygen insufflation corrects etorphine-induced hypoxaemia in chemically immobilized white rhinoceros (Ceratotherium simum).

Abstract

BACKGROUND: Opioid-induced immobilization is associated with severe respiratory depression in the white rhinoceros. We evaluated the efficacy of butorphanol and oxygen insufflation in alleviating opioid-induced respiratory depression in eight boma-managed rhinoceros. RESULTS: Chemical immobilization with etorphine, azaperone and hyaluronidase, as per standard procedure for the white rhinoceros, caused severe respiratory depression with hypoxaemia (PaO2 = 27 &#xb1; 7 mmHg [mean &#xb1; SD]), hypercapnia (PaCO2 = 82 &#xb1; 6 mmHg) and acidosis (pH =7.26 &#xb1; 0.02) in the control trial at 5 min. Compared to pre-intervention values, butorphanol administration (without oxygen) improved the PaO2 (60 &#xb1; 3 mmHg, F (3,21) =151.9, p < 0.001), PaCO2 (67 &#xb1; 4 mmHg, F (3,21) =22.57, p < 0.001) and pH (7.31 &#xb1; 0.06, F (3,21) = 27.60, p < 0.001), while oxygen insufflation alone exacerbated the hypercapnia (123 &#xb1; 20 mmHg, F (3,21) = 50.13, p < 0.001) and acidosis (7.12 &#xb1; 0.07, F (3,21) = 110.6, p < 0.001). Surprisingly, butorphanol combined with oxygen fully corrected the opioid-induced hypoxaemia (PaO2 = 155 &#xb1; 53 mmHg) and reduced the hypercapnia over the whole immobilization period (p <0.05, areas under the curves) compared to the control trial. However, this intervention (butorphanol + oxygen) did not have any effect on the arterial pH. CONCLUSIONS: Oxygen insufflation combined with a single intravenous dose of butorphanol improved the immobilization quality of boma-managed white rhinoceros by correcting the opioid-induced hypoxaemia, but did not completely reverse all components of respiratory depression. The efficacy of this intervention in reducing respiratory depression in field-captured animals remains to be determined.